Research Interests: the group is trying to address questions involving evolutionary and genomic architecture of human diseases. Interdisciplinary and cutting-edge theories and tools from population genetics, molecular evolution, genomics, bioinformatics, molecular physiology, structural biology, etc., are systematically integrated to understand the genetic bases, population processes, and evolutionary origin of human diseases. Specifically, the research interests are comprised of:
1. To identify new genes for human specific complex and Mendelian disorders using techniques, including but not limited to, genomics, transcriptional, proteomics, etc.
2. Research on in vitro features of cell biology of pathogenic genes, "gene-environment", and "gene-drugs" interactions.
3. Research on in vitro gene editing for pathogenic genes.
4. How multiple pathogenic genes inherit and collaborate in networks to play molecular mechanisms.
5. Integrating answers from the specific mutations, gene evolutionary origin, population process, and functional "wet-experiment" assay to achieve precise diagnosis and provide fundamentals for future treatment.